What signifies the Promotion stage in cancer progression?

The Promotion stage in cancer progression is characterized by the growth of already initiated cancer cells. During this stage, specific factors or exposures, such as hormones, chemicals, or lifestyle factors, stimulate the proliferation of these altered cells, allowing them to expand in number. This stage follows the initiation phase, in which genetic changes or mutations occur, and before the progression phase, where further changes lead to increased malignancy or metastasis.

Understanding this concept is crucial for recognizing how cancer develops and why certain interventions or lifestyle modifications can be important in managing cancer risk. In contrast, other options such as an increase in aggressiveness or metastasis represent later phases of cancer progression, while complete remission involves a cessation of cancer activity, which is not relevant to the Promotion stage.